Effects in rats of adolescent exposure to cannabis smoke or THC on emotional behavior and cognitive function in adulthood.

ABSTRACT:

Rationale

Cannabis use is common among adolescents and some research suggests that adolescent cannabis use increases the risk for depression, anxiety, and cognitive impairments in adulthood. In human studies, however, confounds may affect the association between cannabis use and the development of brain disorders.

Objectives

These experiments investigated the effects of adolescent exposure to either cannabis smoke or THC on anxiety- and depressive-like behavior and cognitive performance in adulthood in Long-Evans rats.

Methods

Adolescent rats of both sexes were exposed to either cannabis smoke from postnatal days (P) 29-49 or ascending doses of THC from P35-45. When the rats reached adulthood (P70), anxiety-like behavior was investigated in the large open field and el

SUBMITTER: Bruijnzeel AW 

PROVIDER: S-EPMC6752736 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature