Consistent linear and non-linear responses to invasive electrical brain stimulation across individuals and primate species with implanted electrodes.

ABSTRACT:

Background

Electrical neuromodulation via implanted electrodes is used in treating numerous neurological disorders, yet our knowledge of how different brain regions respond to varying stimulation parameters is sparse.

Objective/hypothesis

We hypothesized that the neural response to electrical stimulation is both region-specific and non-linearly related to amplitude and frequency.

Methods

We examined evoked neural responses following 400 ms trains of 10-400 Hz electrical stimulation ranging from 0.1 to 10 mA. We stimulated electrodes implanted in cingulate cortex (dorsal anterior cingulate and rostral anterior cingulate) and subcortical regions (nucleus accumbens, amygdala) of non-human primates (NHP, N = 4) and patients with intractable epilepsy (N = 15) being monitor

SUBMITTER: Basu I 

PROVIDER: S-EPMC6752738 | biostudies-literature | 2019 Jul - Aug

REPOSITORIES: biostudies-literature