Vancomycin-laden calcium phosphate-calcium sulfate composite allows bone formation in a rat infection model.

ABSTRACT:

Objective

Local antibiotic delivery systems with differing chemical and mechanical properties have been developed to assist in the management of osteomyelitis. We investigated the bone conductive and resorptive capabilities of a calcium phosphate-calcium sulfate (CaP/CaS) composite compared with commercially available polymethylmethacrylate (PMMA). In addition, we compared the in vivo preventative and treatment efficacies of both biomaterials in a proven osteomyelitis model.

Methods

Sixty-four, male Sprague-Dawley rats were inoculated with 10 μl of 1.5 x 108 CFU/ml of Staphylococcus aureus in a surgically drilled defect in the right proximal tibia. Infected animals were randomly allocated into prevention and treatment groups with 32 rats each. In the prevention group, the de

SUBMITTER: Boyle KK 

PROVIDER: S-EPMC6752756 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature