Humoral immunity prevents clinical malaria during Plasmodium relapses without eliminating gametocytes.

ABSTRACT: Plasmodium relapses are attributed to the activation of dormant liver-stage parasites and are responsible for a significant number of recurring malaria blood-stage infections. While characteristic of human infections caused by P. vivax and P. ovale, their relative contribution to malaria disease burden and transmission remains poorly understood. This is largely because it is difficult to identify 'bona fide' relapse infections due to ongoing transmission in most endemic areas. Here, we use the P. cynomolgi-rhesus macaque model of relapsing malaria to demonstrate that clinical immunity can form after a single sporozoite-initiated blood-stage infection and prevent illness during relapses and homologous reinfections. By integrating data from whole blood RNA-sequencing, flow cytometry, P. cyno

SUBMITTER: Joyner CJ 

PROVIDER: S-EPMC6752766 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature