Association between regional brain volumes and BMI z-score change over one year in children.

ABSTRACT:

Purpose

Associations between brain region volume and weight status have been observed in children cross-sectionally. However, it is unclear if differences in brain region volume precede weight gain.

Methods

Two high-quality structural brain images were obtained approximately one year apart in 53 children aged 9-12 years old. Children's height and weight were also measured at each scan. Structural images were processed using the FreeSurfer software-package providing volume measures for regions of interest including the entorhinal cortex, nucleus accumbens, and hippocampus. Age- and sex-adjusted BMI z-scores (BMIz) were calculated at both timepoints. The association between brain region volume and BMIz was examined cross-sectionally using linear regression and longitudinally u

SUBMITTER: Masterson TD 

PROVIDER: S-EPMC6752809 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature