Genetically distinct Group B Streptococcus strains induce varying macrophage cytokine responses.

ABSTRACT: Group B Streptococcus (GBS) is an opportunistic pathogen that causes preterm birth and neonatal disease. Although GBS is known to exhibit vast diversity in virulence across strains, the mechanisms of GBS-associated pathogenesis are incompletely understood. We hypothesized that GBS strains of different genotypes would vary in their ability to elicit host inflammatory responses, and that strains associated with neonatal disease would induce different cytokine profiles than those associated with colonization. Using a multiplexed, antibody-based protein detection array, we found that production of a discrete number of inflammatory mediators by THP-1 macrophage-like cells was universally induced in response to challenge with each of five genetically distinct GBS isolates, while other responses

SUBMITTER: Flaherty RA 

PROVIDER: S-EPMC6752832 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature