Genomic Correlates of Disease Progression and Treatment Response in Prospectively Characterized Gliomas.

ABSTRACT:

Purpose

The genomic landscape of gliomas has been characterized and now contributes to disease classification, yet the relationship between molecular profile and disease progression and treatment response remain poorly understood.Experimental Design: We integrated prospective clinical sequencing of 1,004 primary and recurrent tumors from 923 glioma patients with clinical and treatment phenotypes.

Results

Thirteen percent of glioma patients harbored a pathogenic germline variant, including a subset associated with heritable genetic syndromes and variants mediating DNA repair dysfunctions (29% of the total) that were associated with somatic biallelic inactivation and mechanism-specific somatic phenotypes. In astrocytomas, genomic alterations in effectors of cell-cycle p

SUBMITTER: Jonsson P 

PROVIDER: S-EPMC6753053 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature