Disposable ultrasound-sensing chronic cranial window by soft nanoimprinting lithography.

ABSTRACT: Chronic cranial window (CCW) is an essential tool in enabling longitudinal imaging and manipulation of various brain activities in live animals. However, an active CCW capable of sensing the concealed in vivo environment while simultaneously providing longitudinal optical access to the brain is not currently available. Here we report a disposable ultrasound-sensing CCW (usCCW) featuring an integrated transparent nanophotonic ultrasonic detector fabricated using soft nanoimprint lithography process. We optimize the sensor design and the associated fabrication process to significantly improve detection sensitivity and reliability, which are critical for the intend longitudinal in vivo investigations. Surgically implanting the usCCW on the skull creates a self-contained environment, maintaini

SUBMITTER: Li H 

PROVIDER: S-EPMC6753120 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature