Plasticity in striatal dopamine release is governed by release-independent depression and the dopamine transporter.

ABSTRACT: Mesostriatal dopaminergic neurons possess extensively branched axonal arbours. Whether action potentials are converted to dopamine output in the striatum will be influenced dynamically and critically by axonal properties and mechanisms that are poorly understood. Here, we address the roles for mechanisms governing release probability and axonal activity in determining short-term plasticity of dopamine release, using fast-scan cyclic voltammetry in the ex vivo mouse striatum. We show that brief short-term facilitation and longer short term depression are only weakly dependent on the level of initial release, i.e. are release insensitive. Rather, short-term plasticity is strongly determined by mechanisms which govern axonal activation, including K⁺-gated excitability and the dopam

SUBMITTER: Condon MD 

PROVIDER: S-EPMC6753151 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature