Maternal Obesity Alters Neurotrophin-Associated MAPK Signaling in the Hypothalamus of Male Mouse Offspring.

ABSTRACT:

Purpose

Maternal obesity has emerged as an important risk factor for the development of metabolic disorders in the offspring. The hypothalamus as the center of energy homeostasis regulation is known to function based on complex neuronal networks that evolve during fetal and early postnatal development and maintain their plasticity into adulthood. Development of hypothalamic feeding networks and their functional plasticity can be modulated by various metabolic cues, especially in early stages of development. Here, we aimed at determining the underlying molecular mechanisms that contribute to disturbed hypothalamic network formation in offspring of obese mouse dams.

Methods

Female mice were fed either a control diet (CO) or a high-fat diet (HFD) after weaning until mating and

SUBMITTER: Bae-Gartz I 

PROVIDER: S-EPMC6753176 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature