In vitro antifungal activity of a novel topical triazole PC945 against emerging yeast Candida auris.

ABSTRACT:

Objectives

Management of Candida auris infection is difficult as this yeast exhibits resistance to different classes of antifungals, necessitating the development of new antifungals. The aim of this study was to investigate the susceptibility of C. auris to a novel antifungal triazole, PC945, optimized for topical delivery.

Methods

A collection of 50 clinical isolates was obtained from a tertiary care hospital in North India. Nine isolates from the UK, 10 from a CDC panel (USA) and 3 from the CBS-KNAW culture collection (Japanese and South Korean isolates) were also obtained. MICs (azole endpoint) of PC945 and other triazoles were determined in accordance with CLSI M27 (third edition). Quality control strains were included [Candida parapsilosis (ATCC 22019) and Candida kruse

SUBMITTER: Rudramurthy SM 

PROVIDER: S-EPMC6753477 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature