Effect of patient genetics on etonogestrel pharmacokinetics when combined with efavirenz or nevirapine ART.

ABSTRACT:

Background

We previously demonstrated that etonogestrel concentrations were 82% lower in women using etonogestrel contraceptive implants plus efavirenz-based ART compared with women not receiving ART.

Objectives

To investigate the genetic contribution to this previously observed drug-drug interaction through studying SNPs in genes known to be involved in efavirenz, nevirapine or etonogestrel metabolism in the same group of women.

Patients and methods

Here, we present a secondary analysis evaluating SNPs involved in efavirenz, nevirapine and etonogestrel metabolism and associated etonogestrel pharmacokinetics among 57 women, 19 not receiving ART (control group), 19 receiving efavirenz- (600 mg daily) based ART and 19 receiving nevirapine- (200 mg twice daily) based ART

SUBMITTER: Neary M 

PROVIDER: S-EPMC6753484 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature