Hyaluronic Acid Synthesis Contributes to Tissue Damage in Systemic Lupus Erythematosus.

ABSTRACT: Hyaluronic acid (HA), a component of the extracellular matrix, is the ligand for CD44 and has been implicated in the pathogenesis of kidney inflammation in patients with systemic lupus erythematosus (SLE), but its direct role and mechanism of action have not been studied. Here we show that administration of hymecromone (4-Methylumbelliferone, 4-MU), an HA synthesis inhibitor, to lupus-prone mice suppressed dramatically lupus-related pathology. Interestingly, 4-MU stopped the appearance of disease when administered prior to its onset and inhibited the progression of disease when administered after its appearance. Inhibition of HA synthesis in vivo reduced tissue damage and the number of intrarenal lymphoid cell infiltrates including double negative CD3+CD4-CD8- T cells which are know

SUBMITTER: Suarez-Fueyo A 

PROVIDER: S-EPMC6753633 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature