Fueling Open Innovation for Malaria Transmission-Blocking Drugs: Hundreds of Molecules Targeting Early Parasite Mosquito Stages.

ABSTRACT:

Background

Despite recent successes at controlling malaria, progress has stalled with an estimated 219 million cases and 435,000 deaths in 2017 alone. Combined with emerging resistance to front line antimalarial therapies in Southeast Asia, there is an urgent need for new treatment options and novel approaches to halt the spread of malaria. Plasmodium, the parasite responsible for malaria propagates through mosquito transmission. This imposes an acute bottleneck on the parasite population and transmission-blocking interventions exploiting this vulnerability are recognized as vital for malaria elimination.

Methods

13,533 small molecules with known activity against Plasmodium falciparum asexual parasites were screened for additional transmission-blocking activity

SUBMITTER: Delves M 

PROVIDER: S-EPMC6753678 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature