Evaluation of a simplified optimizer for MR-guided adaptive RT in case of pancreatic cancer.

ABSTRACT:

Purpose

Magnetic resonance-guided adaptive radiotherapy (MRgART) is considered a promising resource for pancreatic cancer, as it allows to online modify the dose distribution according to daily anatomy. This study aims to compare the dosimetric performance of a simplified optimizer implemented on a MR-Linac treatment planning system (TPS) with those obtained using an advanced optimizer implemented on a conventional Linac.

Methods

Twenty patients affected by locally advanced pancreatic cancer (LAPC) were considered. Gross tumor volume (GTV) and surrounding organ at risks (OARs) were contoured on the average 4DCT scan. Planning target volume was generated from GTV by adding an isotropic 3 mm margin and excluding overlap areas with OARs. Treatment plans were generated by using

SUBMITTER: Cusumano D 

PROVIDER: S-EPMC6753732 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature