The co-expression networks of differentially expressed RBPs with TFs and LncRNAs related to clinical TNM stages of cancers.

ABSTRACT:

Background

RNA-binding proteins (RBPs) play important roles in cellular homeostasis by regulating the expression of thousands of transcripts, which have been reported to be involved in human tumorigenesis. Despite previous reports of the dysregulation of RBPs in cancers, the degree of dysregulation of RBPs in cancers and the intrinsic relevance between dysregulated RBPs and clinical TNM information remains unknown. Furthermore, the co-expressed networks of dysregulated RBPs with transcriptional factors and lncRNAs also require further investigation.

Results

Here, we firstly analyzed the deviations of expression levels of 1,542 RBPs from 20 cancer types and found that (1) RBPs are dysregulated in almost all 20 cancer types, especially in BLCA, COAD, READ, STAD, LUAD, LUSC and

SUBMITTER: Lian S 

PROVIDER: S-EPMC6753928 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature