Carbon nanotubes physicochemical properties influence the overall cellular behavior and fate.

ABSTRACT: The unique properties of single walled carbon nanotubes (SWCNTs) make them viable candidates for versatile implementation in the next generation of biomedical devices for targeted delivery of chemotherapeutic agents or cellular-sensing probes. Such implementation requires user-tailored changes in SWCNT's physicochemical characteristics to allow for efficient cellular integration while maintaining nanotubes' functionality. However, isolated reports showed that user-tailoring could induce deleterious effects in exposed cells, from decrease in cellular proliferation, to changes in cellular adhesion, generation of reactive oxygen species or phenotypical variations, just to name a few. Before full implementation of SWCNTs is achieved, their toxicological profiles need to be mechanistically corr

SUBMITTER: Eldawud R 

PROVIDER: S-EPMC6753956 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature