Genome-wide association studies identify susceptibility loci for epithelial ovarian cancer in east Asian women.

ABSTRACT:

Objective

Genome-wide association studies (GWASs) for epithelial ovarian cancer (EOC) have focused largely on populations of European ancestry. We aimed to identify common germline variants associated with EOC risk in Asian women.

Methods

Genotyping was performed as part of the OncoArray project. Samples with >60% Asian ancestry were included in the analysis. Genotyping was performed on 533,631 SNPs in 3238 Asian subjects diagnosed with invasive or borderline EOC and 4083 unaffected controls. After imputation, genotypes were available for 11,595,112 SNPs to identify associations.

Results

At chromosome 6p25.2, SNP rs7748275 was associated with risk of serous EOC (odds ratio [OR] = 1.34, P = 8.7 × 10^-9) and high-grade serous EOC (HGSOC) (OR = 1.34, P = 4.3 × 

SUBMITTER: Lawrenson K 

PROVIDER: S-EPMC6754211 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature