Elevated Thrombospondin 2 Contributes to Delayed Wound Healing in Diabetes.

ABSTRACT: Impaired wound healing is a major complication of diabetes, and despite the associated risks, treatment strategies for diabetic wounds remain limited. This is due, in part, to an incomplete understanding of the underlying pathological mechanisms, including the effects of hyperglycemia on components of the extracellular matrix (ECM). In the current study, we explored whether the expression of thrombospondin 2 (TSP2), a matricellular protein with a demonstrated role in response to injury, was associated with delayed healing in diabetes. First, we found that TSP2 expression was elevated in diabetic mice and skin from patients with diabetes. Then, to determine the contribution of TSP2 to impaired healing in diabetes, we developed a novel diabetic TSP2-deficient model. Though the TSP2-deficient

SUBMITTER: Kunkemoeller B 

PROVIDER: S-EPMC6754242 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature