Nanovaccine Confers Dual Protection Against Influenza A Virus And Porcine Circovirus Type 2.

ABSTRACT:

Background

The influenza A virus (IAV) is known for its high variability and poses a huge threat to the health of humans and animals. Pigs play a central role in the cross-species reassortment of IAV. Ectodomain of matrix protein 2 (M2e) is the most conserved protective antigen in IAV and can be used to develop nanovaccines through nanoparticles displaying to increase its immunogenicity. However, the high immunogenicity of nanoparticles can cause the risk of off-target immune response, and excess unwanted antibodies may interfere with the protective efficacy of M2e-specific antibodies. Therefore, it is necessary to select reasonable nanoparticles to make full use of antibodies against nanoparticles while increasing the level of M2e-specific antibodies. Porcine circovirus type 2 (PC

SUBMITTER: Ding P 

PROVIDER: S-EPMC6754344 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature