Compound danshen dripping pills normalize a reprogrammed metabolism of myocardial ischemia rats to interpret its time-dependent efficacy in clinic trials: a metabolomic study.

ABSTRACT:

Introduction

Clinical trials of Compound danshen dripping pills (CDDP) indicated distinct improvement in patients with chronic stable angina. Daily fluctuation of therapeutic effect agreed with a peak-valley PK profile during a 4-week CDDP regimen, but stabilized after 8-week treatment.

Objectives

This article aims to explore the underlying mechanism for the time-dependent drug efficacy of the up-down fluctuation or stabilization in clinic trials.

Methods

A rat model of myocardial ischemia was established via isoproterenol induction. Metabolomics was employed to analyze the energy-related substances both in circulatory system and myocardium in the myocardial ischemia model.

Results

CDDP treatment ameliorated myocardial ischemia, reversed the reprogramming of th

SUBMITTER: Aa N 

PROVIDER: S-EPMC6754357 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature