Social dominance hierarchy type and rank contribute to phenotypic variation within cages of laboratory mice.

ABSTRACT: A tacit assumption in laboratory animal research is that animals housed within the same cage or pen are phenotypically more similar than animals from different cages or pens, due to their shared housing environment. This assumption drives experimental design, randomization schemes, and statistical analysis plans, while neglecting social context. Here, we examined whether a domain of social context-social dominance-accounted for more phenotypic variation in mice than cage-identity. First, we determined that cages of mice could be categorized into one of three dominance hierarchies with varying degrees of dominance behavior between cage-mates, and low levels of agonistic behavior in the home-cage. Most groups formed dynamic hierarchies with unclear ranks, contrasting with recent accounts of

SUBMITTER: Varholick JA 

PROVIDER: S-EPMC6754368 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature