Ontology highlight
ABSTRACT:
SUBMITTER: Sa JM
PROVIDER: S-EPMC6754410 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Nature communications 20190920 1
Mainstay treatment for Plasmodium vivax malaria has long relied on chloroquine (CQ) against blood-stage parasites plus primaquine against dormant liver-stage forms (hypnozoites), however drug resistance confronts this regimen and threatens malaria control programs. Understanding the basis of P. vivax chloroquine resistance (CQR) will inform drug discovery and malaria control. Here we investigate the genetics of P. vivax CQR by a cross of parasites differing in drug response. Gametocytogenesis, m ...[more]