Emergence of consistent intra-individual locomotor patterns during zebrafish development.

ABSTRACT: The analysis of larval zebrafish locomotor behavior has emerged as a powerful indicator of perturbations in the nervous system and is used in many fields of research, including neuroscience, toxicology and drug discovery. The behavior of larval zebrafish however, is highly variable, resulting in the use of large numbers of animals and the inability to detect small effects. In this study, we analyzed whether individual locomotor behavior is stable over development and whether behavioral parameters correlate with physiological and morphological features, with the aim of better understanding the variability and predictability of larval locomotor behavior. Our results reveal that locomotor activity of an individual larva remains consistent throughout a given day and is predictable throughout l

SUBMITTER: Fitzgerald JA 

PROVIDER: S-EPMC6754443 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature