Ultra-long-acting tunable biodegradable and removable controlled release implants for drug delivery.

ABSTRACT: Here we report an ultra-long-acting tunable, biodegradable, and removable polymer-based delivery system that offers sustained drug delivery for up to one year for HIV treatment or prophylaxis. This robust formulation offers the ability to integrate multiple drugs in a single injection, which is particularly important to address the potential for drug resistance with monotherapy. Six antiretroviral drugs were selected based on their solubility in N-methyl-2-pyrrolidone and relevance as a combination therapy for HIV treatment or prevention. All drugs released with concentrations above their protein-adjusted inhibitory concentration and retained their physical and chemical properties within the formulation and upon release. The versatility of this formulation to integrate multiple drugs and p

SUBMITTER: Benhabbour SR 

PROVIDER: S-EPMC6754500 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature