Association of APOL1 Risk Alleles With Cardiovascular Disease in Blacks in the Million Veteran Program.

ABSTRACT:

Background

Approximately 13% of black individuals carry 2 copies of the apolipoprotein L1 (APOL1) risk alleles G1 or G2, which are associated with 1.5- to 2.5-fold increased risk of chronic kidney disease. There have been conflicting reports as to whether an association exists between APOL1 risk alleles and cardiovascular disease (CVD) that is independent of the effects of APOL1 on kidney disease. We sought to test the association of APOL1 G1/G2 alleles with coronary artery disease, peripheral artery disease, and stroke among black individuals in the Million Veteran Program.

Methods

We performed a time-to-event analysis of retrospective electronic health record data using Cox proportional hazard and competing-risks Fine and Gray subdistribution ha

SUBMITTER: Bick AG 

PROVIDER: S-EPMC6754626 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature