Genome-wide mutation analysis of Helicobacter pylori after inoculation to Mongolian gerbils.

ABSTRACT:

Background

Helicobacter pylori is a pathogenic bacterium that causes various gastrointestinal diseases in the human stomach. H. pylori is well adapted to the human stomach but does not easily infect other animals. As a model animal, Mongolian gerbils are often used, however, the genome of the inoculated H. pylori may accumulate mutations to adapt to the new host. To investigate mutations occurring in H. pylori after infection in Mongolian gerbils, we compared the whole genome sequence of TN2 wild type strain (TN2wt) and next generation sequencing data of retrieved strains from the animals after different lengths of infection.

Results

We identified mutations in 21 loci of 17 genes of the post-inoculation strains. Of the 17 genes, five were outer me

SUBMITTER: Suzuki R 

PROVIDER: S-EPMC6754630 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature