Exploring a Ring-Closing Metathesis Approach to the Archazolid Macrocycle.

ABSTRACT: The synthesis of a new "eastern domain" of a proposed dihydroarchazolid analogue is described along with initial results from attempted macrocyclization by RCM. This work has revealed a competing backbiting process that may be preventable by alcohol functionalization and installation of a metathesis relay.

SUBMITTER: King BR 

PROVIDER: S-EPMC6754729 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature