30-Year Review of Pediatric- and Adult-Onset CVID: Clinical Correlates and Prognostic Indicators.

ABSTRACT:

Purpose

To evaluate mortality risk factors in pediatric-onset common variable immunodeficiency disorders (CVID), we evaluated the largest single-institution cohort of pediatric-onset CVID patients. Previous publications on CVID have provided valuable descriptive data, but lack risk stratification to guide physicians in management of these patients.

Methods

Retrospective chart review of 198 subjects with CVID at a single institution, of whom 91 had disease onset at a pediatric age. Clinical and laboratory data were collected at diagnosis and in follow-up. Odds ratios and Fisher tests were utilized to examine trends. This study was approved by an institutional review board.

Results

Clinical features and laboratory results for subjects diagnosed with CVID at a pediatric

SUBMITTER: Baloh C 

PROVIDER: S-EPMC6754754 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature