Methylome-wide association study provides evidence of particulate matter air pollution-associated DNA methylation.

ABSTRACT:

Background

DNA methylation (DNAm) may contribute to processes that underlie associations between air pollution and poor health. Therefore, our objective was to evaluate associations between DNAm and ambient concentrations of particulate matter (PM) ≤2.5, ≤10, and 2.5-10 μm in diameter (PM_2.5; PM₁₀; PM_2.5-10).

Methods

We conducted a methylome-wide association study among twelve cohort- and race/ethnicity-stratified subpopulations from the Women's Health Initiative and the Atherosclerosis Risk in Communities study (n = 8397; mean age: 61.5 years; 83% female; 45% African American; 9% Hispanic/Latino American). We averaged geocoded address-specific estimates of daily and monthly mean PM concentrations over 2, 7, 28, and 365 days and 1 and 12 mont

SUBMITTER: Gondalia R 

PROVIDER: S-EPMC6754789 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature