The BDNF_Val66Met SNP modulates the association between beta-amyloid and hippocampal disconnection in Alzheimer's disease.

ABSTRACT: In Alzheimer's disease (AD), a single-nucleotide polymorphism in the gene encoding brain-derived neurotrophic factor (BDNF_Val66Met) is associated with worse impact of primary AD pathology (beta-amyloid, Aβ) on neurodegeneration and cognitive decline, rendering BDNF_Val66Met an important modulating factor of cognitive impairment in AD. However, the effect of BDNF_Val66Met on functional networks that may underlie cognitive impairment in AD is poorly understood. Using a cross-validation approach, we first explored in subjects with autosomal dominant AD (ADAD) from the Dominantly Inherited Alzheimer Network (DIAN) the effect of BDNF_Val66Met on resting-state fMRI assessed functional networks. In seed-based connectivity analysis of six major large-scale

SUBMITTER: Franzmeier N 

PROVIDER: S-EPMC6754794 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature