Multi-site investigation of strategies for the clinical implementation of CYP2D6 genotyping to guide drug prescribing.

ABSTRACT:

Purpose

A number of institutions have clinically implemented CYP2D6 genotyping to guide drug prescribing. We compared implementation strategies of early adopters of CYP2D6 testing, barriers faced by both early adopters and institutions in the process of implementing CYP2D6 testing, and approaches taken to overcome these barriers.

Methods

We surveyed eight early adopters of CYP2D6 genotyping and eight institutions in the process of adoption. Data were collected on testing approaches, return of results procedures, applications of genotype results, challenges faced, and lessons learned.

Results

Among early adopters, CYP2D6 testing was most commonly ordered to assist with opioid and antidepressant prescribing. Key differences among programs included test ordering and geno

SUBMITTER: Cavallari LH 

PROVIDER: S-EPMC6754805 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature