The Association between Polymorphisms of Vitamin D Metabolic-Related Genes and Vitamin D₃ Supplementation in Type 2 Diabetic Patients.

ABSTRACT:

Objective

To investigate the effect of single nucleotide polymorphisms (SNPs) of the key genes in vitamin D metabolic pathway on the serum 25(OH)D level after long-term vitamin D₃ supplementation and provide a theoretical basis for rational vitamin D₃ supplementation in diabetic patients with different genetic backgrounds.

Methods

Patients with type 2 diabetes (T2DM) who met the inclusive criteria were given 800 IU of vitamin D₃ daily for 30 consecutive months. Serum 25(OH)D levels was measured at enrollment and every 6 months after enrollment. The average value of four-time measurements represented individual serum 25(OH)D level during vitamin D₃ supplementation. Multiplex TaqMan genotyping was used to determine the distribution o

SUBMITTER: Hu Z 

PROVIDER: S-EPMC6754883 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature