Acute and Subchronic Oral Toxicity of Fermented Green Tea with Aquilariae Lignum in Rodents.

ABSTRACT: Green tea is generally considered safe, but there have been concerns regarding side effects relating to the main component, catechins, especially hepatotoxicities. We have previously shown beneficial effects of fermented green tea with Aquilariae Lignum (fGT) via an oral route in diabetic and obese models. Thus, the toxicological safety of fGT was assessed at limited oral doses for a rodent. Mice or rats of both genders were orally administered distilled water as a control and fGT at 2.0, 1.0, and 0.5 g/kg. There were no mortalities or gross abnormalities in the fGT groups for 2 weeks following the single oral dose in mice. No fGT-relevant abnormalities were found in postmortem and histopathological examinations, suggesting LD₅₀ of fGT at more than 2.0 g/kg with no specific targ

SUBMITTER: Lee S 

PROVIDER: S-EPMC6754909 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature