Crosstalk between Mitochondrial Ca²⁺ Uptake and Autophagy in Skeletal Muscle.

ABSTRACT: Autophagy is responsible for the maintenance of skeletal muscle homeostasis, thanks to the removal of aberrant and dysfunctional macromolecules and organelles. During fasting, increased autophagy ensures the maintenance of the amino acid pool required for energy production. The activity of the mitochondrial Ca²⁺ uniporter (MCU), the highly selective channel responsible for mitochondrial Ca²⁺ uptake, controls skeletal muscle size, force, and nutrient utilization. Thus, both autophagy and mitochondrial Ca²⁺ accumulation play a pivotal role to maintain muscle homeostasis and to sustain muscle function. Here, we address whether, in skeletal muscle, mitochondrial Ca²⁺ uptake and autophagy are mutually related. Muscle-restricted MCU silencing partially

SUBMITTER: Gherardi G 

PROVIDER: S-EPMC6754932 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature