Identification and characterization of circRNAs as competing endogenous RNAs for miRNA-mRNA in colorectal cancer.

ABSTRACT:

Background

Recent studies showed that circRNAs are involved in the biological process of some human cancers. However, little is known about their functions in colorectal cancer (CRC).

Methods

Here we first revealed the expression profiles of circRNAs in the CRC tissues and the adjacent non-tumorous tissues using high-throughput sequencing. The sequence feature, chromosome location, alternative splicing and other characteristics of the circRNAs were also explored. The miRNA and mRNA expression profiles were then obtained by analyzing relevant CRC data retrived from the TCGA database. We obtained and analyzed the competing endogenous RNA (ceRNA) network of the top three pairs of the largest up-regulated and down-regulated circRNAs.

Results

In this study, we obtained 50,

SUBMITTER: Yuan W 

PROVIDER: S-EPMC6754974 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature