Identification of pivotal lncRNAs in papillary thyroid cancer using lncRNA-mRNA-miRNA ceRNA network analysis.

ABSTRACT:

Background

To identify pivotal lncRNAs in papillary thyroid cancer (PTC) using lncRNA-mRNA-miRNA ceRNA network analysis.

Methods

We obtained gene expression profiles from the gene expression omnibus database. Cancer specific lncRNA, cancer specific miRNA and cancer specific mRNA were identified. An integrated analysis was conducted to detect potential lncRNA-miRNA-mRNA ceRNA in regulating disease transformation. The lncRNA regulated gene ontology (GO) terms and regulated pathways were performed by function analysis. Survival analysis was performed for the pivotal lncRNAs.

Results

A total of four lncRNAs, 15 miRNAs and 375 mRNAs are identified as the key mediators in the pathophysiological processes of PTC. GO annotation enrichment analysis showed the most relevant GO

SUBMITTER: Liang W 

PROVIDER: S-EPMC6754980 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature