C-Reactive Protein Gene Variants and Their Serum Levels in Early Adult-onset Type 2 Diabetes Mellitus.

ABSTRACT:

Background/aim

C-Reactive protein (CRP) is a common marker of inflammation. Elevated CRP levels have been associated with increased risk of development of type 2 diabetes mellitus (T2DM). This study aimed to evaluate the association of CRP gene polymorphisms with early-onset T2DM and the effect of genetic variants on CRP level.

Materials and methods

In total, 948 individuals with early-onset (n=271) or late-onset (n=677) T2DM were enrolled in the study. Five single-nucleotide polymorphisms (SNPs) in the CRP gene, namely rs3093077, rs2808630, rs1800947, rs11265263, and rs11265265, were selected for genotyping, and CRP levels were measured.

Results

Genotypic, allelic, and haplotype frequencies of these five SNPs were not significantly different between patients with ear

SUBMITTER: Huang YC 

PROVIDER: S-EPMC6754999 | biostudies-literature | 2019 Sep-Oct

REPOSITORIES: biostudies-literature