MicroRNA-331 inhibits development of gastric cancer through targeting musashi1.

ABSTRACT: BACKGROUND:The molecular mechanisms involved in microRNAs (miRNAs) have been extensively investigated in gastric cancer (GC). However, how miR-331 regulates GC pathogenesis remains unknown. AIM:To illuminate the effect of miR-331 on cell metastasis and tumor growth in GC. METHODS:The qRT-PCR, CCK8, Transwell, cell adhesion, Western blot, luciferase reporter and xenograft tumor formation assays were applied to explore the regulatory mechanism of miR-331 in GC. RESULTS:Downregulation of miR-331 associated with poor prognosis was detected in GC. Functionally, miR-331 suppressed cell proliferation, metastasis and tumor growth in GC. Further, miR-331 was verified to directly target musashi1 (MSI1). In addition, miR-331 inversely regulated MSI1 expression in GC tissues. Furthermore, upregulation

SUBMITTER: Yang LY 

PROVIDER: S-EPMC6755110 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature