MicroRNA‑212 facilitates the motility and invasiveness of esophageal squamous carcinoma cells.

ABSTRACT: As a tumor‑associated microRNA (miR), miR‑212 has dual functions; either as an oncogene or a tumor suppressor. A high expression level of miR‑212 was reported to be associated with poor outcome in patients with esophageal squamous cell carcinoma (ESCC), however, its role in ESCC progression has not been explored. In the present study, an in vitro cell model of lentivirus‑mediated gain‑of‑function demonstrated promotion of ESCC cell migration and invasion when miR‑212 was overexpressed, and no effect on cell proliferation. miR‑212 resulted in downregulation of the expression of E‑cadherin, β‑catenin, vimentin and Twist1. Moreover, it led to increased levels of extracellular matrix (ECM)‑degrading enzymes, matrix metalloproteinase‑9 and urokinase‑type plasminogen activator. Furthermore, berb

SUBMITTER: Chen Z 

PROVIDER: S-EPMC6755231 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature