Analysis of genetic recombination and the pan-genome of a highly recombinogenic bacteriophage species.

ABSTRACT: Bacteriophages are the most prevalent biological entities impacting on the ecosystem and are characterized by their extensive diversity. However, there are two aspects of phages that have remained largely unexplored: genetic flux by recombination between phage populations and characterization of specific phages in terms of the pan-genome. Here, we examined the recombination and pan-genome in Helicobacter pylori prophages at both the genome and gene level. In the genome-level analysis, we applied, for the first time, chromosome painting and fineSTRUCTURE algorithms to a phage species, and showed novel trends in inter-population genetic flux. Notably, hpEastAsia is a phage population that imported a higher proportion of DNA fragments from other phages, whereas the hpSWEurope phages sh

SUBMITTER: Yahara K 

PROVIDER: S-EPMC6755498 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature