Magnesium Regulates Endothelial Barrier Functions through TRPM7, MagT1, and S1P1.

ABSTRACT: Mg²⁺-deficiency is linked to hypertension, Alzheimer's disease, stroke, migraine headaches, cardiovascular diseases, and diabetes, etc., but its exact role in these pathophysiological conditions remains elusive. Mg²⁺ can regulate vascular functions, yet the mechanistic insight remains ill-defined. Data show that extracellular Mg²⁺ enters endothelium mainly through the TRPM7 channel and MagT1 transporter. Mg²⁺ can act as an antagonist to reduce Ca²⁺ signaling in endothelium. Mg²⁺ also reduces the intracellular reactive oxygen species (ROS) level and inflammation. In addition, Mg²⁺-signaling increases endothelial survival and growth, adhesion, and migration. Endothelial barrier integrity is significantly enhanced wi

SUBMITTER: Zhu D 

PROVIDER: S-EPMC6755513 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature