Association of Untargeted Urinary Metabolomics and Lung Cancer Risk Among Never-Smoking Women in China.

ABSTRACT:

Importance

Chinese women have the highest rate of lung cancer among female never-smokers in the world, and the etiology is poorly understood.

Objective

To assess the association between metabolomics and lung cancer risk among never-smoking women.

Design, setting, and participants

This nested case-control study included 275 never-smoking female patients with lung cancer and 289 never-smoking cancer-free control participants from the prospective Shanghai Women's Health Study recruited from December 28, 1996, to May 23, 2000. Validated food frequency questionnaires were used for the collection of dietary information. Metabolomic analysis was conducted from November 13, 2015, to January 6, 2016. Data analysis was conducted from January 6, 2016, to November 29, 2018.

Ex

SUBMITTER: Seow WJ 

PROVIDER: S-EPMC6755532 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature