Association of Birth Weight With Type 2 Diabetes and Glycemic Traits: A Mendelian Randomization Study.

ABSTRACT:

Importance

Observational studies have shown associations of birth weight with type 2 diabetes (T2D) and glycemic traits, but it remains unclear whether these associations represent causal associations.

Objective

To test the association of birth weight with T2D and glycemic traits using a mendelian randomization analysis.

Design, setting, and participants

This mendelian randomization study used a genetic risk score for birth weight that was constructed with 7 genome-wide significant single-nucleotide polymorphisms. The associations of this score with birth weight and T2D were tested in a mendelian randomization analysis using study-level data. The association of birth weight with T2D was tested using both study-level data (7 single-nucleotide polymorphisms were used as

SUBMITTER: BIRTH-GENE (BIG) Study Working Group 

PROVIDER: S-EPMC6755534 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature