Evaluation of Continuous Tumor-Size-Based End Points as Surrogates for Overall Survival in Randomized Clinical Trials in Metastatic Colorectal Cancer.

ABSTRACT:

Importance

Tumor measurements can be used to estimate time to nadir and depth of nadir as potential surrogates for overall survival (OS).

Objective

To assess time to nadir and depth of nadir as surrogates for OS in metastatic colorectal cancer.

Design, setting, and participants

Pooled analysis of 20 randomized clinical trials within the Aide et Recherche en Cancerologie Digestive database, which contains academic and industry-sponsored trials, was conducted. Three sets of comparisons were performed: chemotherapy alone, antiangiogenic agents, and anti-epidermal growth factor receptor agents in first-line treatment for patients with metastatic colorectal cancer.

Main outcomes and measures

Surrogacy of time to nadir and depth of nadir was assessed at the trial lev

SUBMITTER: Burzykowski T 

PROVIDER: S-EPMC6755539 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature