Clinicopathological Characterization and Prognostic Implication of SMAD4 Expression in Colorectal Carcinoma.

ABSTRACT:

Background

SMAD family member 4 (SMAD4) has gained attention as a promising prognostic factor of colorectal cancer (CRC) as well as a key molecule to understand the tumorigenesis and progression of CRC.

Methods

We retrospectively analyzed 1,281 CRC cases immunohistochemically for their expression status of SMAD4, and correlated this status with clinicopathologic and molecular features of CRCs.

Results

A loss of nuclear SMAD4 was significantly associated with frequent lymphovascular and perineural invasion, tumor budding, fewer tumor-infiltrating lymphocytes, higher pT and pN category, and frequent distant metastasis. In contrast, tumors overexpressing SMAD4 showed a significant association with sporadic microsatellite instability. After adjustment for TNM stage, tumor

SUBMITTER: Yoo SY 

PROVIDER: S-EPMC6755646 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature