Redirecting differentiation of mammary progenitor cells by 3D bioprinted sweat gland microenvironment.

ABSTRACT:

Background

Mammary progenitor cells (MPCs) maintain their reproductive potency through life, and their specific microenvironments exert a deterministic control over these cells. MPCs provides one kind of ideal tools for studying engineered microenvironmental influence because of its accessibility and continually undergoes postnatal developmental changes. The aim of our study is to explore the critical role of the engineered sweat gland (SG) microenvironment in reprogramming MPCs into functional SG cells.

Methods

We have utilized a three-dimensional (3D) SG microenvironment composed of gelatin-alginate hydrogels and components from mouse SG extracellular matrix (SG-ECM) proteins to reroute the differentiation of MPCs to study the functions of this microenvironment. MPCs were

SUBMITTER: Wang R 

PROVIDER: S-EPMC6755689 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature