Axin2⁺-Mesenchymal PDL Cells, Instead of K14⁺ Epithelial Cells, Play a Key Role in Rapid Cementum Growth.

ABSTRACT: To date, attempts to regenerate functional periodontal tissues (including cementum) are largely unsuccessful due to a lack of full understanding about the cellular origin (epithelial or mesenchymal cells) essential for root cementum growth. To address this issue, we first identified a rapid cementum growth window from the ages of postnatal day 28 (P28) to P56. Next, we showed that expression patterns of Axin2 and β-catenin within cementum-forming periodontal ligament (PDL) cells are negatively associated with rapid cementum growth. Furthermore, cell lineage tracing studies revealed that the Axin2⁺-mesenchymal PDL cells and their progeny rapidly expand and directly contribute to postnatal acellular and cellular cementum growth. In contrast, the number of K14⁺ epithelia

SUBMITTER: Xie X 

PROVIDER: S-EPMC6755721 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature