Timing Is Everything: Impact of Naturally Occurring <i>Staphylococcus aureus</i> AgrC Cytoplasmic Domain Adaptive Mutations on Autoinduction.

ABSTRACT: Mutations in the polymorphic Staphylococcus aureusagr locus responsible for quorum sensing (QS)-dependent virulence gene regulation occur frequently during host adaptation. In two genomically closely related S. aureus clinical isolates exhibiting marked differences in Panton-Valentine leukocidin production, a mutation conferring an N267I substitution was identified in the cytoplasmic domain of the QS sensor kinase, AgrC. This natural mutation delayed the onset and accumulation of autoinducing peptide (AIP) and showed reduced responsiveness to exogenous AIPs. Other S. aureus strains harboring naturally occurring AgrC cytoplasmic domain mutations were identified, including T247I, I311T, A343T, L245S, and F264C. These mutations were associated with reduced cytotoxi

SUBMITTER: Sloan TJ 

PROVIDER: S-EPMC6755735 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature