Insights into the Physiology and Metabolism of a Mycobacterial Cell in an Energy-Compromised State.

ABSTRACT: Mycobacterium tuberculosis, a bacterium that causes tuberculosis, poses a serious threat, especially due to the emergence of drug-resistant strains. M. tuberculosis and other mycobacterial species, such as M. smegmatis, are known to generate an inadequate amount of energy by substrate-level phosphorylation and mandatorily require oxidative phosphorylation (OXPHOS) for their growth and metabolism. Hence, antibacterial drugs, such as bedaquiline, targeting the multisubunit ATP synthase complex, which is required for OXPHOS, have been developed with the aim of eliminating pathogenic mycobacteria. Here, we explored the influence of suboptimal OXPHOS on the physiology and metabolism of M. smegmatisM. smegmatis harbors two identical copies of atpD, which codes for the β subunit of ATP synthase.

SUBMITTER: Patil V 

PROVIDER: S-EPMC6755754 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature